Effect of combination of Yindan Xinnao Tong Soft Capsule and atorvastatin, Clopidogre Tablets on blood lipid, carotid artery plaque, and neurological function recovery in patients of acute cerebral infarction with type 2 diabetes / 中草药

ABSTRACT

Objective: To investigate the effect of the combination of Yindan Xinnao Tong Soft Capsule (YXTSC) and atorvastatin, Clopidogre Tablets on blood lipid, carotid atherosclerosis (CAS) plaque, and the neurological function recovery in the patients of acute cerebral infarction with type 2 diabetes. Methods: One hundred and fifty patients (CAS plaque in them was confirmed by carotid artery color Doppler ultrasound) with acute cerebral infarction and diabetes in Tianjin Hospital during May form 2013 to 2015 were seleted and randomly divided into two groups, 75 cases in each group. On the basis of basic disease treatment for the patients in the two groups, the patients in the control group were given Atorvastatin Tablet of 10 mg/d and Clopidogre Tablets of 75 mg/d, orally once daily. On the basis of the control group treatment, the patients in the treatment group were given YXTSC (0.4 g/capsulae) three capsules once and three times daily. The patients in both groups were given diet control and their blood pressure, blood sugar, and other drug treatments were controlled according to the disease. The blood lipid level was observed before and after the treatment for 12 months in the two groups, the total number of CAS plaque was calculated, the plaque intima media thickness (IMT) was measured, and the nature of the change was determined. The neurological function score, curative effect judgment, and the statistics of the end events between the two groups were carried at the end of the treatment. Results: After the treatment, the serum TC, LDL-C, and TG were reduced, HDL-C of the patients in the two groups increased, while the LDL-C of the patients in the treatment group was lower than that of the patients in the control group significantly (P < 0.05); The IMT of the patients in the two groups was significantly lower than that of patients before the treatment, but the plaque area of the patients in the treatment group was smaller than that of the patients in the control group significantly (P < 0.05); The scores of nervous function of the patients in treatment group were significantly lower than those of the patients in the control group; The curative effect of the treatment group was better than that of the control group (P < 0.01). The incidence of adverse drug reactions in treatment group was lower than that in the control group (P < 0.05). Conclusion: The combination of YXTSC and atorvastatin could effectively treat hyperlipidemia and CAS plaque in cerebral infarction patients associated with type 2 diabetes.