Preparation and characterization of curumin solid dispersion using mesoporous silica nanoparticle / 中草药

ABSTRACT

Objective: Taking mesoporous silica nanoparticle (MSN) as carrier, to prepare curcumin (Cur)-MSN-solid dispersion (SD) for study on its effect on the dissolution rate and solubility of Cur. Methods: MSN was prepared by condensation method and Cur-MSN-SD was obtained using solvent evaporation method. Then, Cur-MSN-SD was characterized with scanning electron microscope, nitrogen adsorption test, infrared spectrum analysis, and differential scanning calorimetry. Then the dissolution rate and solubility between Cur and Cur-MSN-SD were compared. Results: The average pore diameter of prepared MSN was 2.737 nm, with the feature of typical mesoporous structure, and Cur was distributed in the channel. The cumulative dissolution rate and solubility of the drug were the best as the mass ratio of Cur to MSN was 1∶4. Conclusion: The Cur-MSN-SD prepared with the MSN as carrier could improve the cumulative dissolution rate and solubility of Cur, which provides an effective method for solving the water non-solubility of Cur.