Advances in studies on anti-oxidant mechanism of curcumin based on signal transduction pathway / 中草药

ABSTRACT

Curcumin is one of the polyphenolic compounds, which is the biological active ingredient of Curcuma longa. Studies indicate a beneficial role of curcumin in terms of anti-oxidant, anti-tumourgenic, and anti-inflammatory properties. And H-atom transfer is a preferred anti-oxidant mechanism of curcumin. Curcumin activates the Nrf2-ARE, NF-κB, NADPH oxidase/ROS, Notch, AMPK/eNOS, and MAPK signal transduction pathways, induces or inhibits signaling molecules and functional gene, modulates the protein expression, increases anti-oxidant enzyme activities, and counteracts oxidative stress.