Revalidation of key role of water absorption in disintegration process of Chinese materia medica dispersible tablets: Exemplifying by Jianghuang Qingzhi Dispersible Tablets / 中草药

ABSTRACT

Objective: The purpose of this paper is to verify the key role of water absorption in the process of disintegration of Chinese materia medica (CMM) dispersible tablets, so as to provide the solution idea for slow disintegration of CMM dispersible tablets. Methods: In this paper, the influence of water absorption of raw materials and auxiliary materials on disintegration process was verified using oily Jianghuang Qingzhi Tablets (JQT) as research object. The water absorption and disintegrating process of different drugs, JQT with different materials, and modified dispersible tablet were determined. Results: The water absorption of JQT was lower than that of lactose tablets, and the disintegrating process was slower. The water absorption of different materials prescription of JQT was CMS-Na-PVPP (1∶1) > PVPP > CMS-Na, and disintegrating process is the same as the former order. The water absorption of JQT after modification enhanced, and disintegration time was significantly shortened. It indicated that the water absorption of raw materials and excipients was stronger, the disintegration was faster. Conclusion: The study proves that water absorption is a key role in the disintegration of CMM dispersible tablets. And co-grinding of silica powder and raw materials is important technology to solve the problem of slow disintegration of CMM dispersible tablets.