Chemical constituents from fruiting bodies of Amauroderma rude / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 881-885, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853633
ABSTRACT
Objective:
To study the chemical constituents from the fruiting bodies in Amauroderma rude of family Ganodermataceae.Methods:
The constituents were separated by column chromatography and their structures were elucidated by spectral data analyses. The cytotoxicities of compounds were evaluated using MTT methods.Results:
Twelve compounds were isolated and identified from the fruiting bodies of A. rude and were identified as diptoindonesin D (1), 6-deoxyjacareubin (2), jacareubin (3), 1H-indole-3-carboxylic acid (4), methyl 3,4-dihydroxybenzoate (5), 3,4-dihydroxyphenylethanol (6), 3β-hydroxy-7, 22E-dien-ergosta (7), 3β, 7α-dihydroxy-8,22E-5α, 6α-epoxyergosta (8), 3β-hydroxy-7α-methoxy-8 (14), 22E-dien-5α, 6α-epoxyergosta (9), ergosterol 5α, 8α-peroxide (10), 3β-5β-8β-trihydroxy-6, 22E-ergosta (11), and 3β, 5α-6β-trihydroxy-7, 22E-dien-ergosta (12). Compounds 2 and 3 exhibited the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines and compound 9 showed the cytotoxic activities against HL-60, MCF-7, and SW-480 cell lines.Conclusion:
All the compounds are obtained from this fungus for the first time. Compounds 2,3, and 9 show the definite cytotoxicities against five cell lines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
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