Chemical constituents from Actinostemma lobatum (II) / 中草药

ABSTRACT

Objective: To investigate the chemical constituents from the whole plant of Actinostemma lobatum. Methods: The chemical constituents were isolated from the 75% alcohol extract of A. lobatum by silica column chromatography, C18, Sephadex LH-20 columns, and RP-HPLC. Their chemical structures were elucidated on the basis of physicochemical and spectral properties, 1H-NMR, and 13C-NMR. Results: Twelve compounds were isolated and identified as lobatoside B (1), tubeimoside II (2), tubeimoside V (3), gallic acid (4), methyl gallate (5), protocatechuic acid (6), protocatechuic acid methyl ester (7), 4-hydroxyacetophenone (8), p-hydroxybenzoic acid (9), p-hydroxybenzaldehyde (10), 5-(hydroxymethyl)-2-furaldehyde (11), and 1-[5-(hydroxymethyl) furan-2-yl] ethanone (12). Conclusion: Compounds 2 and 5-12 are isolated from the plants in Actinostemma Griff. for the first time.