Chemical constituents from ethyl acetate extract of Sappan Lignum / 中草药

ABSTRACT

Objective: To study the chemical constituents in Sappan Lignum (the core material of Caesalpinia sappan). Methods: The chemical constituents of Sappan Lignum were isolated by different column chromatographic techniques, including silica gel and Sephadex LH-20 columns. The structures of these compounds were identified by a comprehensive analysis on the spectroscopic data. Results: Fifteen compounds were isolated from the EtOAc extract of Sappan Lignum. The compounds were identified as protosappanin A (1), 3,7-dihydroxychroman-4-one (2), 7,3',4'-trihydroxy-3-benzyl-2H-chromene (3), bonducellin (4), 3'-deoxysappanol (5), 3'-deoxy-4-O-methylepisappanol (6), 3-deoxysappanchalcone (7), 3,8,9-thihydroxy-6H-benzo[c] chromen- 6-one (8), 3,9-dihydroxy-8-methoxydibenzo [b, d] pyran-6-one (9), (-)-syringaresinol (10), dibutyl phthalate (11), β-sitosterol (12), β-daucosterol (13), stigmasterol (14), and 1-heneicosanol (15). Conclusion: Compounds 9, 11, and 12 are first isolated from the plants of Caesalpinia Linn. and compound 4 is first isolated from this plant.