Preparation and quality evaluation of resveratrol orally disintegrating tablets / 中草药

ABSTRACT

Objective: The process of preparing resveratrol orally disintegrating tablets was researched, the best prescription was determined and the quality of resveratrol orally disintegrating tablets about dissolution and micromeritics were evaluated. Methods: The optimal prescription of direct powder compression method was determined by adopting Box-Benhnken center combination experiment design, with universal evaluation indexes, including disintegration time, mouthfeel, and hardness. The accumulative dissolution was tested by using dissolution test. The micromeritics about the angle of repose, loose density, tap density, and compressibility index were evaluated. Results: The optimal prescription were 50 mg resveratrol (22.5%), 63.5 mg MCC (28.6%), 18.6 mg PVPP (8.4%), 10 mg L-HPC (4.5%), 78 mg (35.1%), and 2 mg magnesium stearate (0.9%). The disintegration time of resveratrol orally disintegrating tablets prepared with the optimized prescription was qualified. More than 90% resveratrol was dissoluted within 10 min. The micromeritics showed that the powder had good fluidity and filling property. Conclusion: The process of preparation for orally disintegrating tablets by using direct compression method is feasible, it is easy to operate, and this method can meet the requirement in industry.