Preparation of glycyrrhetinic acid niosomes and optimization of its prescription process / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 240-245, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853755
ABSTRACT
Objective:
With nonionic surfactants as the carrier material to prepare glycyrrhetinic acid (GC) niosomes (NI) and to evaluate the quality.Methods:
The thin film dispersion-ultrasound method was used for establishing the preparation process of GC - NI, reverse dialysis method and ultraviolet spectrophotometer method were used to determine the encapsulation efficiency (EE), the prescription and preparation process were optimized through single factor and central composite design-response surface methodology (CCD-RSM), and the properties of morphology, particle size, Zeta potential, and EE in optimized NI were investigated.Results:
The optimum prescription process as Span 80-cholesterol was 21, hydration temperature was 70℃, hydration time was 51 min, ultrasonic time was 60 min, its forecast EE was 80.66%, bias between the observed and predicted values was 4.95%, and regression coefficient of binomial fitting complex model was as high as 0.989 9.Conclusion:
CCD-RSM is used to optimize the preparation, which has the stable, feasible, high precision, and good predictability advantage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
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