Effects of Shufengjiedu Capsule on model of viral myocarditis in mice / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 110-113, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-853789
ABSTRACT
Objective:
To investigate the effect of Shufengjiedu Capsule on the modality of myocardial tissue and levels of serum TNF-α and SAA in mice with viral myocarditis.Methods:
BALB/C mice were randomly divided into normal control group, virus group, Shufengjiedu Capsule 0.1, 0.2, 0.5 g/kg/d groups, and ribavirin 0.1 g/kg/d group. The mouse model of viral myocarditis was established by ip injection of CVB3, and after 2 h of modeling, the animals were continuously admistered for 7 d. Half of the mice were killed on days 4 and 8, the myocardium tissue was HE stained to observe the pathological changes and blood samples were taken for measurement of serum TNF-α and SAA contents.Results:
Compared with the control group, the pathological changes of myocardium were significantly decreased in high-dose Shufengjiedu Capsule group, and the serum TNF-α and SAA contents were significantly decreased (P < 0.05).Conclusion:
Shufengjiedu Capsule has antiviral effect and could alleviate the inflammation on mice with viral myocarditis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS