Preparation of emulsion-hydrogel transdermal patch of essential oil from Artemisiae Argyi Folium and its transdermal characteristics / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3661-3665, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-853807
ABSTRACT
Objective:
To optimize formulations of emulsion-hydrogel transdermal patch of essential oil from Artemisia Argyi Folium, and to evaluate its transdermal characteristics in vitro.Methods:
The formulations were optimized by orthogonal experiment with four factors including hydrogel patch carrier (sodium polyacrylate NP-700), crosslinking agent (dihydroxyaluminium aminoacetate), crosslinking modifier (EDTA), and moisturizing agent (glycerol). Initial adhesive force, hold force, 180° peeling strength, cohesion, and permeability were measured. In addition, the contents of eucalyptol, camphor, and borneol in hydrogel transdermal patch were analyzed by GC.Results:
The impacting factors which affected the patch shaping were in the order of glycerol > dihydroxyaluminium aminoacetate > EDTA > sodium polyacrylate NP-700. The optimized formulation was as following 30% glycerol, 5% NP-700, 0.3% dihydroxyaluminium aminoacetate, and 0.03% EDTA. The permeation rates of eucalyptol, camphor, and borneol were 85.216, 4.442, and 3.941 μg/(cm2∙h), respectively.Conclusion:
Emulsion-hydrogel transdermal patch of essential oil from Artemisia Argyi Folium has a better quality and a transdermal property of zero-order release process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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