Advance in studies on matrixsustained-release preparation of Chinese materia medica for oral / 中草药

ABSTRACT

Components of matrix sustained-release preparation of Chinese materia medica (CMM) are complex, the multi-component and multi-target features of the pharmacological require the synchronous release of all the components, which are also influenced by the difference of their physicochemical properties. The article summarizes the effect of the multi-component on the synchronous release of CMM from hydrophilic matrix materials, infusibility matrix materials, bioerodible matrix materils, and mixed matrix materials by reviewing the related literatures, in order to provide the reference for the further research and development of multicomponent skeleton sustained-release preparation.