Flocculation effect of chitosan flocculant on water-extraction solution of Xiaoyan Tuire Granules Oral Liquid / 中草药

ABSTRACT

Objective: To optimize the purifying process of water-extraction solution of Xiaoyan Tuire Granules Oral Liquid by flocculation clarifying method, reserve more active components while less impurities, and improve the clarity of oral liquid. Methods: After clearing out the impurities composition of water-extraction solution of Xiaoyan Tuire Granules Oral Liquid, the flocculant of chitosan chosen by screening test was used to analyze the flocculation effect. The retention rate of aesculetin, the removal rate of impurity, and supernatant turbidity were set as mainly indexes to estimate the influence of the dosage of flocculant, temperature, fast mixing speed, and fast mixing time. Results: The optimal flocculating process conditions which were analyzed by experiments were as follows the dosage of chitosan was 1.25 g/L, the flocculation temperature was 40 ℃, the fast mixing speed was 350 r/min, and the fast mixing time was 3 min. Under these conditions, the retention rate of aesculetin was 88.92%, the removal rates of protein and tanning were 62.96% and 67.19%, the supernatant turbidity was 5.0 NTU after the oral liquid was flocculated for 24 h. Conclusion: Using chitosan as flocculant in the water-extraction solution of Xiaoyan Tuire Granules Oral Liquid, it could improve the removal rate of impurities effeitively as well as keep higher active components and enhance the clarity of oral liquid.