Chomones from fruit of cnidium monnieri and their effects on proliferation of UMR106 cells / 中草药

ABSTRACT

Objective: To study the chomenes from the fruit of Cnidium monnieri and their effects on proliferation of UMR106 cells. Methods: The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The effects of all isolated compounds on proliferation of osteoblast-like UMR106 cells were determined. Results: Ten compounds were isolated and identified as cnidimoside A (1), cnidimol B (2), peucenin (3), 5,7-dihydroxychromone (4), 5-O-methylvisamminol (5), 4'-O-β-D-glucosyl-5-O-methylvisamminol (6), hamaudol (7), 2,5-dimethyl-7-hydroxychromone (8), cimifugin (9), and 5-hydroxy-chromone-7-O-β-D-glucoside (10). Compounds 1,5,9, and 10 showed the significant proliferative activities against UMR106 cells lines at the concentration of 0.10 nmol/L and the proliferative ratios were 30.23%, 31.56%, 35.29%, and 33.36%. Conclusion: Compounds 3-10 are isolated from species of genus Cnidium Cuss. for the first time. Compounds 1,5,9, and 10 (0.10 nmol/L) could increase the proliferation of UMR106 cells to some extent.