The Time Course and Determinants of B-Type Natriuretic Peptide in Healthy Men during Supine Bicycle Exercise
Journal of the Korean Society of Echocardiography
;
: 17-22, 2004.
Article
in Korean
| WPRIM
| ID: wpr-85399
ABSTRACT
BACKGROUND AND OBJECTIVES:
Circulating B-type natriuretic peptide (BNP) has been used as a marker of left ventricular hypertrophy and heart failure, and known to be increased after exercise in healthy men as well as patients with left ventricular dysfunction. However, the relationship between exercise duration and BNP level, and the determinants of circulating BNP concentration during exercise have not been fully elucidated. For these reason, we measured circulating BNP level during exercise, and exercise-induced changes of cardiac function by echocardiography in healthy men. MATERIALS ANDMETHODS:
Ten healthy male volunteers (mean age 27+/-3 year-old) underwent symptom-limited bicycle ergometer in supine position for 30 min. The workload started at 25 W for 6 min with increment of 50 W every 3 min. Blood samples for BNP were obtained at baseline, every 1 min for first 3 min, 25 W, 75 W, 125 W, peak exercise and 10 min after resting.RESULTS:
BNP level was increased only at peak exercise (mean5.3+/-0.5 vs 7.7+/-4.1 pg/ml, median5.0 vs 6.3 pg/ml, p<0.05), not during submaximal exercise, and sustained 10 minutes after exercise (190+/-25 watt, 14.9+/-12 min). Peak BNP level was significantly correlated with baseline BNP level (r=0.723, p<0.05), E' (0.18+/-0.04 vs 0.29+/-0.08 m/sec, r=-0.649, p<0.05) and E/E' (4.18+/- 0.87 vs 5.66+/-2.31, r=0.769 p<0.01) by bivariate correlation analysis, but correlated with only baseline BNP level by multiple linear regression analysis (p<0.05).CONCLUSION:
Circulating BNP concentration was minimally increased only after peak exercise in young healthy men, not increased at submaximal exercise The BNP concentration after exercise is only determined by baseline BNP level, not by duration and workload of exercise.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Volunteers
/
Echocardiography
/
Linear Models
/
Supine Position
/
Hypertrophy, Left Ventricular
/
Ventricular Dysfunction, Left
/
Natriuretic Peptide, Brain
/
Echocardiography, Stress
/
Heart Failure
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Journal of the Korean Society of Echocardiography
Year:
2004
Type:
Article
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