A new compound of isoflavanones from fruits of Psoralea corylifolia and its cytotoxicity / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2206-2208, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-854041
ABSTRACT
Objective:
For the purpose of finding new bioactive agents from Chinese herbal medicine, the chemical study on Psoralea corylifolia was carried out.Methods:
The chemical constituents in the fruits of P. corylifolia were isolated by silica gel, MCI-GEL resin, Sephadex LH-20 column chromatography, and high performance liquid chromatography (HPLC) methods. The structures of compounds were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques.Results:
A new isoflavanone, 3R-6-hydroxy-8-(hydroxymethyl)-4',7-dimethoxy-dihydrogenisoflavone (1) was isolated from the fruit of P. corylifolia.Conclusion:
Compound 1 is a new compound named corylisoflavone A, which displays the cytotoxicity against NB4, SH-SY5Y, PC3, A549, and MCF7 cells with IC50 values of 12.6, 5.3, 15.5, 4.8, and 11.2 μmol/L, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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