Chemical constituents of Aganosma marginata / 中草药

ABSTRACT

Objective: To investigate the chemical constituents from Aganosma marginata and to provide the material basis for the quality control. Methods: The chemical constituents were separated and purified by silica gel Sephadex LH-20, MCI. Their structures were determined by physicochemical properties and spectral data analyses. Results: Twenty three compounds were isolated from A. marginata and identified as periseoside C (1), 3-O-β-D-glucopyranosyl-3β,15α-dihydroxypregn-5-en-20-one (2), 3β,20α-dihydroxy- 5-en-pregane (3), 28-methylstigmast-5-en-3-ol (4), 29-norcycloart-23-ene-3,25-diol (5), 29-norcycloartan-3-ol (6), geniposidic acid (7), syringaresinol (8), syringaresinol-4,4'-O-bis-β-D-glucopyranoside (9), syringic acid 4-O-β-D-glucopyranoside (10), salicylic acid (11), scopoletin (12), azelaic acid (13), 3-O-[β-D-xylopyranosyl]-(1→4)-β-D-allopyranoside-14-hydroxycard-20 (22)-enolide (14), bis (2-ethylhexyl) phthalate (15), kaempferol-3-O-α-L-rhamnopyranosyl-(l→4)-α-L-glucopyranoside (16), kaempferol-3-O-α-L- glucopyranoside-(1→2)-β-D-glucopyranoside (17), kaempferol-3-O-α-L-rhamnopyranosyl-(1→4)-[α-L-rhamnopyranosyl (1→4)]-β- D-glucopyranoside (18), kaempferol-3-O-α-L-rhamnopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranoside (19), hexacosanoicacid 1-carbonate (20), 5,8,12-trihydroxy-9-octadecenoic acid (21), (2S,3S,4R)-phytosphingosine (22), and nebularine (23). Conclusion: All the compounds are obtained from plants of Aganosma G. Don for the first time.