Effect of kaempferol on correlation factors of chronic complications of type 2 diabetic rats / 中草药

ABSTRACT

Objective: To observe the effect of kaempferol on the correlation factors of chronic complications of type 2 diabetic rats. Methods: Feeding high-fat diet combined with ip injection of 30 mg/kg STZ in rats to make the model of type 2 diabetes. Rats in every administration group were given respective drug (50, 100, and 200 mg/kg), and set the model, normal control, and positive control (metformin hydrochloride 0.2 g/kg) groups. After 10 weeks, using glucose oxidase to measure blood glucose of rats in each group; Radioimmunoassay was used to measure INS and get ISI. Measuring the contents of TG, HDL-C, LDL-C, SOD, AR, IL-6, TNF-α, and MDA was detected by TBA. Results: Compared with diabetic model group, kaempferol administration can reduce blood glucose and insulin resistance, restore normal blood lipid levels, along with reducing MDA, AR, TNF-α, and IL-6 levels and increasing SOD levels. Conclusion: Kaempferol can prevent and treat the chronic complications of type 2 diabetic rats by reducing blood glucose, insulin resistance, reducing the AR pathway as well as anti-oxidation and anti-inflammation.