Chemical constituents from roots of Campanumoea javanica and their antiangiogeneic activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 470-475, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-854173
ABSTRACT
Objective:
To study the chemical constituents from the roots of Campanumoea javanica and their antiangiogenesis activities.Methods:
The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis, the antiangiogenic activities of the isolated compounds were evaluated using a zebrafish model.Results:
Fourteen compounds were isolated and identified from 90% ethanol extract in ethyl acetate fraction in the roots of C. javanica, including campanumoside (1), lobetyol (2), tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol (3), 9-(tetrahydropyran-2-yl)-non-trans- 8-ene-4,6-diyn-3-ol (4), 9-(tetrahydropyran-2-yl)-nona-trans,trans-2,8-diene-4,6-diyn-1-ol (5), lobetyolinin (6), (Z)-3-hexenyl-O- α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (7), 3,4-dihydroxybenzoic acid (8), tangshenoside II (9), zanthocapensol (10), ampelopsin (11), agathisflavone (12), β-ecdysterone (13), and α-tocopherolquinone (14).Conclusion:
Compound 1 is a new polyacetylene glucoside named campanumoside. Compounds 2-14 are isolated from the plants of Campanumoea Bl. for the first time. Compounds 3 and 4 exhibit the certain antiangiogenic activity in the pharmacological evaluation with a zebrafish model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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