Diterpenoids from Aquilariae Lignum Resinatum (III) / 中草药

ABSTRACT

Objective: To study the chemical constituents of small polar in Aquilariae Lignum Resinatum. Methods: The column chromatography on silica gel, Sephadex LH-20, and semi-preparative HPLC was used to separate and purify the compounds, their structures were elucidated by NMR and MS spectroscopic data analyses. Results: Nine compounds were isolated from the petroleum ether of Aquilariae Lignum Resinatum and identified as 18-nor-abieta-8,11,13-triene-4α,7α-diol (1), 18-norabieta-8,11,13-triene-4α, 7β-diol (2), 7α-hydroxydehydroabietic acid (3), 2α-hydroxydehydroabietic acid (4), 2β-hydroxydehydroabietic acid (5), 7α,15- dihydroxy-methyl-dehydroabietate (6), 7-oxo-13β-hydroxyabiet-8(14)-en-18-oic acid (7), 2β-hydroxypimaric acid (8), and 3β- hydroxypimarol (9). Conclusion: All the compounds are isolated from the plants of Aquilaria Lam. for the first time, among them, compounds 1 and 2 are norditerpenoids and compounds 3-9 are diterpenoids.