Chemical constituents in stems of Neocinnamomum delavayi / 中草药

ABSTRACT

To investigate the chemical constituents in the stems of Neocinnamomum delavayi. The compounds were isolated by silica gel, MCI gel, RP-18, Sephadex LH-20 column chromatographies and semi-preparative HPLC, and the structures were elucidated by spectroscopic analysis. Seventeen compounds were isolated from the 80% EtOH extract in the stems of N. delavayi, including four phenolic glucosides, three lignans, six sesquiterpenoids, three flavonoids, and one sterol. They were identified as 6-O-syringoyl-1-O-vanilloyl-β-D-glucopyranoside (1), 6-O-acetyl-1-O-(3, 4, 5-trimethoxyphenyl)-β-D-glucopyra-noside (2), 1, 6-di-O-syringoyl-β-D-glucopyranoside (3), 3, 4, 5-trimethoxyphenyl-6-O-syringoyl-β-D-glucopyranoside (4), lirioresinol B dimethyl ether (5), sesartemin (6), (+)-9'-O-(E)-feruloyl-5, 5'-dimethoxylariciresinol (7), oplodiol (8), cryptomeridiol (9), 4-epicryptomeridiol (10), 7α, 11-dihydroxy-cadin-10 (14)-ene (11), (-)-clovane-2, 9-diol (12), phaseic acid (13), catechin (14), epicatechin (15), trans-dihydroquercetin (16), and (24S)-24-ethylcholsta-3β, 5α, 6β-triol (17). Compounds 1 and 2 are two new phenolic glucosides named neocinnamosides A and B, respectively, while compounds 3-17 are isolated from the plants of genus Neocinnamomum Liou for the first time.