Influence of different compatibility for Improved Peach Gum to balance release of complex components / 中草药

ABSTRACT

Objective: To clarify the influence of the different combinations (consumption, fillers) of Improved Peach Gum to the balance release of complex components. Methods: Use Chuanping Prescription as model drug, Improved Peach Gum as sustained release materials, the release test companied with HPLC was applied to determine the accumulated release rate of the index components (ephedrine, pseudoephedrine, scopolamine) in Chuanping Sustained-release Tablets, calculate the cumulative release curve slope K value, and to evaluate the balance release of the different components. Results: The study on different combinations, when the filler is starch, starch/dextrin, and starch/MCC, the index component cumulative release curves were close to slope K value and can achieve the balance release; match with dextrin and MCC, the slope K values are different and can not achieve the balance release. With increasing the amount of Improved Peach Gum, release time prolonged, cumulative release slope K values of index components are basically same and can achieve balance release. Conclusion: Different fillers match with Improved Peach Gum can affect the balance release of complex components of Chinese materia medica; Different amount of Improved Peach Gum will affect the drug release time, but not affect on balance release.