Determination of related substances in Diammonium Glycyrrhizinate Enteric Coated Tablet by LC-MS / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 365-368, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-854312
ABSTRACT
Objective:
To establish the methods for identifying the related substances in Diammonium Glycyrrhizinate Enteric Coated Tablet (DGECT) by ultra high performance liquid-diode array-ion trap-the time of flight tandem mass spectrometry (UPLC-DAD-IT- TOF-MS).Methods:
The chromatographic separation was performed on an Agilent HC-C18 (250 mm × 4.6 mm, 5 μm) column, mobile phase was acetonitril-H2O-Hac (3806146), eluting sample was in equal degree flow, with volume flow rate of 1 mL/min, UV detection wavelength of 254 nm, and mass spectrum monitoring mass-to-charge ratio range m/z 100-1000.Results:
Including licoricesaponine G2, H2, E2, B2, J2, C2, 18α-glycyrrhizic acid, and glycyrrhiza uralensis saponin (A or B), the eight kinds of related compounds existed were found.Conclusion:
The related substances found in DGECT are valuable for the manufacturing process and quality control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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