Exploration on biological networks relationship between effects of Danlou Tablets on cardiovascular disease and their relative components / 中草药

ABSTRACT

By systematically searching through the literature databases, such as PubMed, China National Knowledge Infrastructure (CNKI), and WanFang database and applying Ingenuity Pathway Analysis (IPA) software, we have identified the potential disease targets and forecasted the possible mechanisms of several chemical components in Danlou Tablets. We found that the pharmacological study on Danlou Tablets in recent years mainly focused on hyperlipidemia and atherosclerosis. And some of the identified chemical components have been shown to exert such effects through the cyclooxygenase 2 (PTGS2), leptin (LEP), nitric oxide synthase (NOS3), and low density protein receptor (LDLR). However, it remains a great challenge in identifying the key active chemical components of Danlou Tablets and elucidating their pharmacological effects. The combination of the chemical biology and network pharmacology approaches will facilitate our understanding on the cardiovascular disease specificity and mechanisms of the action for Danlou Tablets.