Isoflavones from flower buds of Rosa rugosa and their cytotoxicity / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1420-1422, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-854368
ABSTRACT
Objective:
To study the chemical constituents from the flower buds of Rosa rugosa.Methods:
The chemical constituents from the flower buds of R. rugosa were isolated by silica gel, MCI-gel resin, Sephadex LH-20 column chromatography and high performance liquid chromatography (HPLC) methods. Their structures were elucidated by spectroscopic methods and physicochemical properties.Results:
Three isoflavones, 6,8-dihydroxy-4',7-dimethoxyisoflavone (1), prunetin (2), and pratensein (3) were isolated from the flower buds of R. rugosa.Conclusion:
Compound 1 is a new compound named rosa isoflavone. Compounds 2 and 3 are isolated from R. rugosa for the first time. Compound 1 displays the stronger cytotoxicity against A549 and PC3 cells with IC50 values of 2.6 and 3.2 μmol/L, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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