Comparison on blood tonic effects of Jiaoai Decoction and Siwu Decoction on blood deficiency model rats / 中草药

ABSTRACT

Objective: To compare the effects of Jiaoai Decoction and Siwu Decoction on peripheral hemogram, immune organ, and energy metabolism enzyme activity in blood deficiency model rats, and investigate the mechanism of Jiaoai Decoction derived as a tonic effect of Siwu Decoction after the change. Methods: Taking every day on the fundus venous plexus put blood 5 mL/kg, 12 d continuous bleeding, to establish the rat model of blood deficiency, the red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), platelet (PLT), immune organ index, and energy metabolism enzyme activity were detected. Results: Compared with the normal control group, RBC, HGB, HCT, and PLT could be significantly decreased (P2+-Mg2+-ATP and Na+-K+-ATP enzyme activity could be decreased significantly (P2+-Mg2+-ATP and Na+-K+-ATP enzyme activity could be enhanced (P2+-Mg2+-ATP enzyme activity could be enhanced (P+-K+-ATP enzyme activity was significantly weaker than that in the mid-dose group of Jiaoai Decoction. Conclusion: Jiaoai Decoction and Siwu Decoction have the effect of enriching the blood in different degrees, Jiaoai Decoction evolved into Siwu Decoction could decrease the efficacy of enriching the blood.