Comparative study on in vivo pharmacokinetics of tetramethylpyrazine, ferulic acid, and tetrahydropalmatine between model and normal rats / 中草药

ABSTRACT

Objective: To study the in vivo pharmacokinetic law and difference of active compounds from Chuanxiong Rhizoma and Corydalis Rhizoma between control and model rats. Methods: Sixteen Sprague-Dawley rats were randomly divided into two groups control and model rats with endometriosis, eight rats in each group. All the rats were ig administrated of tetramethylpyrazine (50 mg/kg), ferulic acid (30 mg/kg), and tetrahydropalmatine (20 mg/kg). All the concentration of tetramethylpyrazine, ferulic acid, and tetrahydropalmatine in plasma was analyzed by RP-HPLC and the data were treated by DAS 2.0 program. Results: The main pharmacokinetic parameters of tetramethylpyrazine in the model group, such as AUC0~t, Cmax, tmax, t1/2, and MRT0~t, were no significant difference compared with the control group (P > 0.05), and AUC0~t, Cmax, and tmax of ferulic acid in model group were less than those in the control group with no significant difference (P > 0.05); t1/2 and MRT0~t of ferulic acid in the model group were obviously less than those in control group (P0~t, Cmax, tmax, and MRT0~t of tetrahydropalmatine in the model group were bigger than those in the control group with significant difference (P < 0.05). Conclusion: There is difference of pharmacokinetics of the main active compounds from Chuanxiong Rhizoma and Corydalis Rhizoma between model and control rats. Ferulic acid is removed more quickly in model rats, tetrahydropalmatine is absorbed highly but removed slower, tetramethylpyrazine is no significant difference comparee with the control group.