Advances in study on baicalein for regulation of signaling pathways in myocardial ischemia/hypoxia / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1685-1691, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-854426
ABSTRACT
Myocardial ischemia/hypoxia often results in damaging the structure and function of heart. Baicalein, a widely distributed flavonoid, has been shown to play an important role in the cardioprotection of ischemia/hypoxia in recent years. The cardioprotection of baicalein was mediated by regulating the cell signaling pathways and controlling the phosphorylation of key signaling molecules. These signaling pathways involved in phosphatidylinositol-3-kinase-serine/threonine kinase (PI3K/Akt), mitogen-activated protein kinase (MAPKs), and nuclear factor-κB (NF-κB), and their down signaling proteins HMGB1, MMP-2/-9, and eNOS, and apoptosis proteins as well. The interaction mechanism of baicalein on signaling pathway in myocardial ischemia/hypoxia has been reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2015
Type:
Article
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