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Optimization of damp-proof excipients for Gushuling Granules / 中草药
Chinese Traditional and Herbal Drugs ; (24): 2005-2008, 2014.
Article in Chinese | WPRIM | ID: wpr-854453
ABSTRACT

Objective:

To evaluate the effect of the excipients on hygroscopicity of Gushuling Granules and optimize the damp-proof excipients.

Methods:

Moisture absorption rate was used to optimize the type and ratio of materials; The concentration of ethanol, moisture absorption rate, formability, angle of repose, and appearance of Gushuling Granules were used to optimize the molding technology.

Results:

The best damp-proofing excipients were as follows the hybrid materials were lactose-mannitol 41, medicine-auxiliary ratio of 12, and with 85% ethanol to granulate. Gushuling Granules were good uniform, damp-proofing, and formability, the critical relative humidity was 76%.

Conclusion:

The preparation technology is stable. The study provides the experimental evidences for the research and development of Gushuling Granules.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2014 Type: Article