Research progress on antidepressive mechanism of Xiaoyaosan via metabolic network regulation / 中草药

ABSTRACT

The anti-depressive effect of Xiaoyaosan is obvious; However, the potential mechanism remains unclear. This paper elucidated the antidepressive mechanism of Xiaoyaosan from the fields of neurotransmitter, neurotrophins, hypothalamic-pituitary- adrenal axis, metabolisms of amino acid, lipid, and energy, inflammatory factor, and metabolic network figure. The comprehensive results implicate that Xiaoyaosan plays as antidepressant via the role of action on multiple targets and regulation in the metabolic balance in vivo.