Optimization for formulation of Zhi Xiong San thermo-sensitive gel by central composite design-response surface method and study on characterization of its nasal mucosal permeability / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1845-1849, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854481
ABSTRACT
Objective:
To prepare and optimize the formulation of intranasal thermo-sensitive gel of Zhi Xiong San and to evaluate its in vitro release mechanism and nasal mucosa permeability.Methods:
The formulations of poloxamer thermo-sensitive gel were optimized by a central composite design-response surface method and its in vitro release mechanism and nasal mucosa permeability were evaluated by Franz diffusion chambers.Results:
The optimal formulation was Poloxamer 407 (P407) 20% and Poloxamer 188 (P188) 6.5%. Imperatorin was released from the thermo-sensitive gels approximately with a zero-order mechanism, while ferulic acid with a Higuchi model. The formulation demonstrated the enhancement of nasal mucosa permeability.Conclusion:
The optimal formulation provides a basis for the development of new administration routes and dosage forms of Zhi Xiong San.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
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