Solidifying of ginkgo flavones phospholipid complex using colloidal silica / 中草药

ABSTRACT

Objective: To prepare ginkgo flavones phospholipid complex (GF-PC) and to solidify it using colloidal silica (CS). Methods: CS was used as a carrier to solidify GF-PC. The structures of the phospholipid complex and solidified powder were also characterized by differential scanning calorimetry, X-ray diffractomer, and scanning electron microscope, and dissolution in vitro and fluidity were also investigated. Results: The phase analysis indicated that ginkgo flavones existed in the phospholipid complex and solidified powder as amorphous state. Dissolution in vitro showed that the solidified powder could effectively promote the drug dissolution. Conclusion: The process of the solidified powder is simple and convenient. The powder prepared can significantly improve the fluidity of the GF-PC and promote the dissolution in vitro.