In vivo pharmacokinetic and targeting study on silybin solid lipid nanoparticles modified by folic acid / 中草药

ABSTRACT

Objective: The silybin solid lipid nanoparticles (SIL-SLN), which is connected folic acid (FA) active targeting head, were studied on the in vivo pharmacokinetics of rats and in vivo targeting of mice. Methods: SIL solution, SIL-SLN, and FA-SIL-SLN were iv injected by tail of rats or mice, respectively. The SIL concentration in the plasma and tissues was detected by HPLC method at different time points. The in vivo pharmacokinetic characteristics in rats and in vivo targeting data in mice were analyzed by statistical methods with 3P97 software. Results: Compared with solution group and SIL-SLN group, FA-SIL-SLN has good sustained-release ability and long-cycle characteristics, re value of the lung in FA-SIL-SLN is 3.98 times higher than that in the control group, and te value is 2.85 times higher than that in the SIL solution group; Meanwhile, it can reduce the drug distribution in heart and kidney. Conclusion: The in vivo tests show that SIL-SLN and FA-SIL-SLN have the obvious sustanined-release effect and lung targeting, and also can reduce the toxicity of drugs in heart and kidney.