Chemical constituents of Solidago virgaurea and their anti-inflammatory activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 749-754, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854641
ABSTRACT
Objective:
To study the chemical constituents of Solidago virgaurea and their pharmacological activities.Methods:
The compounds were isolated and purified from the plant with chromatography techniques and the chemical structures were identified on the basis of spectrascopic analyses and physicochemical properties, and the anti-inflammatory effects of obtained benzyl benzoate compounds were evaluated by ELISA.Results:
Nine compounds were isolated from 90% ethanol extract of S. virgaurea and their structures were identified as 2'-methoxybenzyl-2-methoxy-6-hydroxybenzoate (1), 2'-methoxybenzyl-2, 6-dimethoxybenzoate (2), solidagobenzofuran (3), hexadecanoic acid (4), salicylic acid (5), p-hydroxybenzoic acid (6), solidago virgaurea glycoside (7), kaempferol-3-O-β-D-rutinoside (8), and rutin (9).Conclusion:
Compounds 3 and 7 are new compounds; Compounds 4 and 6 are obtained from the plants of Solidago L. for the first time; Compounds 1 and 2 are isolated from this species for the first time. Anti-inflammatory studies show that compounds 1 and 2 could inhibit the TNF-α and IL-6 release of LPS-induced RAW264.7 murine monocytes, while compound 7 shows no significant inhibitory effect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS