Study on balanced release of Chuanping extract sustained-release tablets combined with different accessories / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 774-777, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854646
ABSTRACT
Objective:
To study the balanced release of complex components of Chuanping extract sustained-release tablets combined with different accessories.Methods:
With methamphetamine, pseudoephedrine, and scopolamine as indexes, HPLC and the in vitro release test were applied to determining the accumulated release rate of the complex components in nine sustained-release Chuanping extract preparations (Q1-Q9), and to evaluating the influences of different accessories to the release behaviors of complex components in vitro.Results:
The differences about dissolutions of four single modern materials in Chuanping extract sustained-release tablets Q1-Q3 were significant, and Q4 released fast. All of them were not balanced release. The differences about dissolutions of single improved Chinese materia medica (CMM) sustained-release accessories made Chuanping extract sustained-release tablets Q5 were significant, and Q6 was balanced release. The difference about dissolutions of complex improved CMM sustained release excipients made Chuanping extract sustained-release tablets Q9 was incomplete, the balanced release of Q8 was not well. The balanced-release of complex components of Q7 was well.Conclusion:
Different accessories would affect the balanced release of sustained-released Chuanping extract tablet in vitro. The modern sustained-release accessories are hard to achieve the balanced release of complex components of CMM compound sustained-release preparations, but the improved traditional sustained-release accessories could be achieved well.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
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