Persistent α-Fetoprotein Elevation in Healthy Adults and Mutational Analysis of α-Fetoprotein Promoter, Enhancer, and Silencer Regions
Gut and Liver
;
: 136-141, 2017.
Article
in English
| WPRIM
| ID: wpr-85466
ABSTRACT
BACKGROUND/AIMS:
α-Fetoprotein (AFP) is normally 1 year, and 20 controls with low AFP levels (<0.61 to 2.9 ng/mL) were included in the study. AFP levels were collected from the families of two of the patients. We sequenced five regions that are critical for AFP expression a promoter, two enhancers, and two silencers.RESULTS:
One of the two cases in which family information was represented is the first case of hereditary persistence of AFP in South Korea. Mutations related to AFP overexpression were not found in the transcription regulatory regions among the four patients.CONCLUSIONS:
Persistent AFP elevation is a heterogeneous condition with or without a hereditary pattern and may be caused by factors outside of transcription regulatory region changes. Further research on the mechanism of AFP elevation is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA Mutational Analysis
/
Biomarkers
/
Alpha-Fetoproteins
/
Regulatory Sequences, Nucleic Acid
/
Korea
/
Liver Regeneration
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Gut and Liver
Year:
2017
Type:
Article
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