Chemical constituents from Ficus pumila / 中草药

ABSTRACT

Objective: To investigate the chemical constituents from Ficus pumila and to provide the material basis for quality control. Methods: The chemical constituents were separated and purified by silica gel, Sephadex LH-20, ODS, and preparative HPLC column chromatographies. Their structures were determined by physicochemical properties and spectral data analyses. Results: From 95% ethanol extract of F. pumila, 21 compounds were isolated and identified as rutin (1), kaempferol 3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (2), isoquercitrin (3), quercitrin (4), dihydrokaempferol 5-O-β-D-glucopyranoside (5), dihydro-kaempferol 7-O-β-D-glucopyranoside (6), maesopsin 6-O-β-D-glucopyranoside (7), secoisolariciresinol 9-O-β-D-glucopyranoside (8), chlorogenic acid (9), protocatechuic acid (10), caffeic acid (11), 5-O-caffeoyl quinic acid methyl ester (12), p-hytroxybenzoic acid (13), vanillic acid (14), 5-O-caffeoyl quinic acid butyl ester (15), β-amyrin acetate (16), daucosterol (17), phaseic acid (18), vomifoliol (19), (1'S, 6'R)-8'-hydroxyabscisic acid β-D-glucoside (20), and 1-methyl-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid (21). Conclusion: Compounds 5-15, 18, 20, and 21 are isolated from this plant for the first time, and compound 5-8, 12, 15, 20, and 21 are found in plants of Ficus Linn. for the first time.