Chemical constituents in root tubers of Euphorbia kansui and their activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3383-3386, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854728
ABSTRACT
Objective:
To study the isolation and identification of the chemical constituents in the root tubers of Euphorbia kansui and screen the cytotoxic activity of monomer compounds.Methods:
The silica gel column chromatography and high performance liquid chromatography (HPLC) methodx were used. The structures were identified by the spectrum data analysis (MS, 1H-NMR, and 13C-NMR); The cytotoxic activity of monomer compounds was determined by MTT method.Results:
Nine compounds were identified from the ethyl acetate part, respectively. They were kansuinin B (1), 3-O-(2, 3-dimethylbutanoyl)-13-O-dodecanoyl-ingenol (2), 5-O-benzoyl-20-deoxyingenol (3), euphol (4), isoscopletin (5), adenosine (6), hydroxytyrosol (7), 2', 4', 7-trihydroxy isoflavone (8), and emodin (9). Among them compound 1 is jatrophane-type diterpene, compounds 2 and 3 are the ingenane-type diterpenes, compound 4 is triterpene compound.Conclusion:
Compounds 6-8 are isolated from this plant for the first time. Compounds 1 and 9 have the good inhibition on intestinal epithelial cells ICE-6.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
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