Synthesis of mono-carbonyl curcumin analogues containing nitrogen heterocyclic ring and their anti-inflammatory activities / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 3532-3537, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854741
ABSTRACT
Objective:
A series of mono-carbonyl curcumin analogues containing nitrogen heterocyclic ring were designed and synthesized and their anti-inflammatory activities were detected.Methods:
A mixture of thiophen-2-acryloyl chloride and compounds containing nitrogen heterocyclic ring reacted to yield the target compounds, and the structures were identified using 1H-NMR and ESI-MS. The anti-inflammatory activity of these compounds was detected by mouse macrophages producing pro-inflammatory cytokines TNF-α and IL-6 induced by LPS.Results:
Thirteen target compounds were synthesized, and some of these compounds could significantly inhibit the production of inflammatory cytokines, especially compound Z5 exhibited the most inhibitory activity.Conclusion:
Compounds Z1, Z5, and Z9-Z13 are new compounds, and compound Z5 could be used as the candidate of anti-inflammatory drug.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS