Pharmacokinetic study on Danshen Decoction with multiple dosing to awake animal by blood microdialysis method combined with LC-MS / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2206-2209, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-854809
ABSTRACT
Objective:
To carry out the pharmacokinetic study in awake animal after multiple dosing of Danshen (Salvia miltiorrhiza) Decoction by blood microdialysis method combined with LC-MS.Methods:
The pharmacokinetic study was carried out with awake rabbits as experimental animal, Danshen Decoction as tool drug, and Danshensu as evaluation index combining with microdialysis sampling and LC-MS detection technology after intraday multiple dosing. The pharmacokinetic parameters were obtained by non-compartmental model method.Results:
The pharmacokinetic study pattern of multiple dosing was established in awake animal, and the whole process dynamic characteristics were collected. The method was stable, reliable, and simple.Conclusion:
This study can make the reference to similar study for other drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article
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