Therapeutic effect of Atalantia buxifolia on chronic bronchitis and its mechanism / 中草药

ABSTRACT

Objective: To evaluate the effect of the ethanol extract and active parts from the roots of Atalantia buxifolia on chronic bronchitis (CB) and their mechanism. Methods: The rat model of CB was established with smoking method of sulfur dioxide, ethanol extract and active parts from the roots of A. buxifolia were ig administrated, the pathological changes of lung tissue in rats were analyzed, and the level changes of interleukin-10 (IL-10), interleukin-4 (IL-4), and tumor necrosis factor-α (TNF-α) were determined by ELISA method. Results: The administration of ethanol extract and n-butanol extract could improve the tiredness and weakness of CB rats, reduced food intake, and body weight without increasing status, decrease the degree of infiltration, epithelial cell shedding, bronchial secretion, inhibit the proliferation of bronchial epithelial cells of the rat bronchial inflammatory cells, and make the bronchial diameter increases and ventilation. The low dose of the ethanol extract and n-butanol extract could significantly inhibit the increase of TNF-α, IL-10, and IL-4 in the lung tissue of rats with CB in the homogenate, compared with the model group with the statistical significance (P0.05). Conclusion: The alcoholic extract and n-butanol extract in the roots of A. buxifolia have the better treatment effect on CB, which may be related to the balance of cytokine production related.