In vivo metabolic pathway of liquiritin in rats / 中草药
Chinese Traditional and Herbal Drugs
; (24): 2499-2505, 2014.
Article
in Zh
| WPRIM
| ID: wpr-854861
Responsible library:
WPRO
ABSTRACT
Objective: To study the in vivo metabolic pathways of liquiritin (LQ) in rats. Methods: An HPLC-QTRAP-MS method was established and applied to identify the metabolites of LQ in bile, urine, feces, and plasma after ig administration of LQ (300 mg/kg) to rats. Results: A total of nine metabolites were found in rats. The major metabolic pathway of LQ was deglucosidation to liquiritigenin (LG) and dehydration, glucuronidation, and sulfation of LG. Conclusion: LQ undergoes extensive phases I and II metabolism in rats. The major metabolites of LQ are LG and its glucuronides and sulfates.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Traditional and Herbal Drugs
Year:
2014
Type:
Article