Research on medication regularity of pattern of internal accumulation of zhuodu in chronic atrophic gastritis based on correspondence between prescription and syndrome / 中草药

ABSTRACT

To study the medication regularity of Huazhuo Jiedu Formula in treating the chronic atrophic gastritis (CAG), and to explore the stable relationship of correspondence between Huazhuo Jiedu Formula and the pattern of internal accumulation of zhuodu. Statistical analysis was conducted among 200 cases of CAG, whose case histories included their gender, age, electronic gastroscope, pathological results, clinical symptoms, and prescriptions of Chinese materia medica. On the basis of "golden section method", the association rule between drugs and syndromes was investigated using frequency statistic method and association rule analysis. Through data processing, 153 kinds of Chinese herbal decoction were obtained. According to the principle of "golden section method", 15 kinds of Chinese herbal decoction, whose frequency of use was over 61.8% (including 61.8%), were used as the therapeutical core drugs of pattern of internal accumulation of zhuodu in CAG. Ten kinds of clinical symptoms, which had the high ocurrence rate, were the main symptoms of the pattern of internal accumulation of zhuodu in CAG. According to association rules analysis, it was found that there was a strong correlation between drugs and pulses, which explained the high degree of correspondence of prescription and syndromes between the pattern of internal accumulation of zhuodu in CAG and Huazhuo Jiedu Decoction. It can be seen that there exists a relationship of correspondence between Huazhuo Jiedu Formula and the pattern of internal accumulation of zhuodu in CAG. And it shows that the key pathogenesis of CAG is internal accumulation of zhuodu, and the corresponding treatment is Huazhuo Jiedu Method.