Comparison on in vitro dissolution behavior of notoginsenoside R1, ginsenosides Rb1 and Rg1 between ordinary fine and ultrafine powder of Panax notoginseng / 中草药

ABSTRACT

Objective: To compare the dissolution behavior of notoginsenoside R1, ginsenoside Rb1 and Rg1 between the ordinary fine and ultrafine powder of Panax notoginseng and to investigate the effect of micronization on the dissolution of saponin ingredients in P. notoginseng. Methods: The oar method was adopted. The in vitro dissolution of the three kinds of saponins including notoginsenoside R1, ginsenoside Rg1 and Rb1 in different particle sizes was determined by HPLC. The dissolving rates of the powder in various particle sizes were compared. Results: The dissolving rates of the three kinds of saponins were greatly increased after ultramicro-pulverization. Conclusion: The ultramicro-pulverization is helpful to the dissolution of saponins in P. notoginseng pieces, and the particle size of the powder exerts the great influence on the dissolution of the three kinds of saponins.