Optimization of ultrafiltration technology for Xiangdan Injection / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 2988-2991, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-855060
ABSTRACT
Objective:
To explore the effect of ultrafiltration technology in the preparation of Xiangdan Injection on transmittance and impurity removal rates of protocatechuic aldehyde (PA) and sodium danshensu (SD), to evaluate its applicability, and to optimize the ultrafiltration technology.Methods:
Taking the solution temperature, pH value, intercept relative molecular weight of ultrafiltration membrane, membrane import and export pressure difference of ultrafiltration membrane as influence factors, the process parameters of the ultrafiltration were optimized by detecting the contents and solid contents of PA and SD before and after the ultrafiltration.Results:
The three factors of temperature, pH value, and import and export pressure difference have no significant influence on the transmittance of PA and SD, and the removal rate of impurity. The intercept relative molecular weight of ultrafiltration membrane has the significant influence (P < 0.01).Conclusion:
The optimized ultrafiltration conditions are feasible for the preparation of Xiangdan Injection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional and Herbal Drugs
Year:
2013
Type:
Article
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