Synthesis of theophylline molecular imprinted polymer microspheres and their properties / 中草药

ABSTRACT

Objective: To snythesize theophylline molecular imprinted polymer (MIP) microspheres. The influences of reaction conditions, including the category of solvent, reaction time, and the ratio of template to the cross-linking agent on the morphology and adsorption properties of MIP microspheres were studied. Methods: Theophylline MIP microspheres were prepared by precipitation polymerization with theophylline as template and ethyleneglycol dimethacrylate (EGDMA) as cross-linker. The microspheres were characterized by static adsorption and scanning electron microscopy (SEM). Results: The ratio of template to the cross-linking agent was 116, reaction time was 24 h, and acetontrile was the solvent. The theophylline MIP microspheres were regular microspheres. The MIP microspheres showed the high adsorption capacity and the partition coefficient of the microspheres adsorbing theophylline was 1.74. Conclusion: Theophylline MIP microspheres have the specific adsorption and recognition capabilities to the theophylline molecules.