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Preparation of sinomenine hydrochloride nanoparticle thermosensitive gel for intra-articular injection and its characteristic investigation / 中草药
Chinese Traditional and Herbal Drugs ; (24): 1899-1904, 2013.
Article in Chinese | WPRIM | ID: wpr-855223
ABSTRACT

Objective:

To prepare the solid lipid nanoparticle (SLN) thermosensitive gel of sinomenine hydrochloride (SH) for intra-articular injection and to investigate its in vitro drug release behavior.

Methods:

Poloxamer 407 (P-407) and Poloxamer 188 (P-188) were used as gel matrix to prepare the gel, and the gelatinization temperature was applied as a target to optimize the prescription. The SH-SLN was prepared based on the microemulsion technique, and the gel system containing SH-SLN was obtained by cold-dissolving methods. The content of SH was determined by HPLC, in vitro release characteristics of SH-SLN thermosensitive gel were investigated by dialysis method.

Results:

The optimal gel prescription was finally confirmed as 18% P-407, 5% P-188, and 0.6% HPMC. The gelatination temperature for SH-SLN thermosensitive gel was (34.5 ± 0.2)°C, and the in vitro accumulated release rates of SH in the SLN thermosensitive gel system were (57.79 ± 0.36)% after 24 h and (75.16 ± 0.12)% after 48 h.

Conclusion:

The SH-SLN thermosensitive gel has the temperature sensitivity and obvious sustained-release effect. The combination of nanoparticle thermosensitive gel will be used as a new drug delivery for intra-articular injection.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional and Herbal Drugs Year: 2013 Type: Article