Matrix formulation optimizing of Periplaneta americana Cream by D-optimal mixture design / 中草药

ABSTRACT

Objective: To optimize the matrix formulation of Periplaneta americana Cream. Methods: To optimize the blank matrix formulation by D-optimal mixture design, using presentation, spread property, centrifugal stability, cold stability, and thermostability as evaluating indicators, and to investigate the dosage of P. americana extract. Results: The matrix formulation of P. americana Cream was as follows glycerol 11.00 g, stearic acid 14.00 g, triethanolamine 3.50 g, atolein 18.00 g, petrolin 10.00 g, water 43.50 g, and the amount of P. Americana extract 1.0 g. Conclusion: D-optimal mixture design is an effective and systematic method which could optimize the matrix formulation to reach the optimum presentation and physical property.