Chemical constituents from seeds of Taxus yunnanensis / 中草药

ABSTRACT

Objective: To study the chemical constituents from the seeds of Taxus yunnanensis. Methods: The chemical constituents in the seeds of T. yunnanensis were isolated by chromatography and identified by a comprehensive analysis on the spectral data. Results: Twelve taxanes were isolated from the seeds of T. yunnanensis and identified as 7-epi-10-deacetyltaxol (1), 2-deacetoxytaxuspine C (2), 9α-hydroxy-2α, 7α, 10β-triacetoxy-5α-cinnamoyloxy-3, 11-cyclotaxa-4(20)-en-13-one (3), 2α-acetoxy-5α-cinnamoyloxy-9α, 10β-dihydroxy-taxa-4 (20), 11-diene-13-one (4), dantaxusin C (5), taxezopidine H (6), 9-deacetyltaxinine A (7), 5α-decinnamoyltaxagifine (8), taxumairol B (9), 2α, 5α, 13α-trihydroxy-7β, 9α, 10β-triacetoxy-taxa-4(20), 11-diene (10), 7, 9, 10, 13-tetra-O-deacetylabeobaccatin VI (11), and taxacustin (12). Conclusion: Compounds 2, 3, and 7-12 are isolated from T. yunnanensis for the first time.