Studies on chemical constituents of Guizhi Fuling Capsule (IV) / 中草药

ABSTRACT

Objective: To investigate the chemical constituents from the petroleum ether and ethyl acetate extract of Guizhi Fuling Capsule (GFC). Methods: The compounds were separated with chromatography on silica gel and polydextran gel columns, and prep-HPLC, and their chemical structures were identified by NMR and MS spectral methods, respectively. Results: Eight compounds were isolated from the petroleun ether extract and were identified as coumarin (1), 7-hydroxycoumarin (2), cinnamic alcohol (3), ergosterol (4), ergosta-4, 6, 8 (14), 22-tetraen-3-one (5), β-amyrin acetate (6), campesterol (7), and α-amyrin acetate (8). Thirteen compounds were isolated from the ethyl acetate extract and were identified as apingenin (9), kaemferol (10), quercetin (11), kaempferol-3-O-glucopyranoside (12), catechin (13), epicatechin (14), syringic acid (15), hyperin (16), eicosanoids (17), syringaresinol (18), mudanpioside A (19), mudanpioside C (20), and galloylpaeoniflorin (21). Conclusion: Compounds 1-21 are isolated from GFC for the first time.